醫學領域 ChatGPT 的 10 個提問範例

這裡介紹的是在醫學領域，如何用 ChatGPT 生成實用的提示問句 (prompt) 範例，然後再套用提示句型來做詢問，以得到摘要資訊和相關實證文獻。

Prompt 提示

I am a medical doctor dedicated to evidence-based medicine. Please give me 10 useful prompt examples for querying ChatGPT in order to get high quality evidence medical literature.

中文：
我是致力於實證醫學的醫生。請提供 10 個有用的範例提示，以便在查詢 ChatGPT 時獲取高品質的醫學文獻。

ChatGPT 的回應

Here are 10 useful prompt examples for querying ChatGPT to get high-quality evidence-based medical literature:

  1. “Provide a systematic review on the effectiveness of [specific treatment] for [specific condition].”

  2. “Summarize the latest clinical guidelines for the management of [specific disease] from [reputable medical organization].”

  3. “What are the outcomes of randomized controlled trials comparing [treatment A] and [treatment B] in patients with [specific condition]?”

  4. “Find meta-analyses on the long-term effects of [specific medication] in the treatment of [specific disease].”

  5. “List the key findings from cohort studies investigating the risk factors for [specific disease].”

  6. “Summarize the consensus statements from [specific medical society] on the treatment of [specific condition].”

  7. “What are the latest recommendations for screening and prevention of [specific disease] according to [reputable guideline source]?”

  8. “Provide an overview of the evidence on the safety and efficacy of [specific procedure] in [patient population].”

  9. “What are the most recent findings on the genetic markers associated with [specific disease]?”

  10. “Summarize the current evidence on the use of [specific intervention] in improving outcomes for patients with [specific chronic condition].”

These prompts can help you obtain high-quality, evidence-based medical literature that is relevant to your needs.

中文：
這裡有10個有用的範例提示，用於在查詢ChatGPT時獲取高品質的實證醫學文獻：

  1. “請提供關於[特定治療]對[特定病症]效果的系統評價。”

  2. “請總結來自[知名醫療機構]的最新[特定疾病]處理臨床指南。”

  3. “比較[治療A]和[治療B]在[特定病症]患者中的隨機對照試驗結果如何？”

  4. “找出關於[特定藥物]在治療[特定疾病]中的長期效果的綜合分析。”

  5. “列出研究[特定疾病]危險因素的隊列研究中的關鍵發現。”

  6. “總結[特定醫學會]關於[特定病症]處理的共識聲明。”

  7. “根據[知名指南來源]，最新的[特定疾病]篩查和預防建議是什麼？”

  8. “請提供關於[特定程序]在[患者群體]中安全性和有效性的證據概述。”

  9. “關於[特定疾病]相關基因標記的最新發現是什麼？”

  10. “總結目前使用[特定介入措施]改善[特定慢性病]患者結果的證據。”

這些提示可以幫助你獲取與你需求相關的高品質實證醫學文獻。

Example 應用例子

prompt

I am a medical doctor dedicated to evidence-based medicine.
Provide an overview of the evidence on the safety and efficacy of semaglutide in obesity.
List relevant academic papers.

ChatGPT 的回應

Overview of the Evidence on the Safety and Efficacy of Semaglutide in Obesity

Semaglutide, a GLP-1 receptor agonist, has been extensively studied for its efficacy and safety in the treatment of obesity. Here is an overview of the key findings from relevant academic literature:

Efficacy

  1. Weight Loss:

    • Semaglutide has been shown to induce significant weight loss in obese patients. Studies consistently report that patients treated with semaglutide experience greater reductions in body weight compared to those receiving placebo.
    • The STEP 1 trial demonstrated a mean weight loss of approximately 15% of body weight with semaglutide 2.4 mg weekly, compared to 2.4% with placebo【40†source】【41†source】.

  2. Maintenance of Weight Loss:

    • Long-term studies indicate that semaglutide helps maintain weight loss. The STEP 4 trial showed that continued treatment with semaglutide significantly improved weight loss maintenance compared to placebo over a 68-week period【41†source】.

  3. Improvement in Comorbidities:

    • Semaglutide not only aids in weight reduction but also improves several obesity-related comorbidities, such as hypertension, dyslipidemia, and impaired glucose metabolism【42†source】.

Safety

  1. Common Side Effects:

    • The most frequently reported side effects are gastrointestinal in nature, including nausea, vomiting, and diarrhea. These side effects are usually mild to moderate in severity and tend to decrease over time【41†source】【42†source】.

  2. Serious Adverse Events:

    • The incidence of serious adverse events is low. Some studies noted a slight increase in the risk of gallbladder-related events and pancreatitis, though these are relatively rare【40†source】【41†source】.

  3. Cardiovascular Safety:

    • Semaglutide has demonstrated a favorable cardiovascular safety profile. It does not increase the risk of major adverse cardiovascular events (MACE) and may even provide some cardiovascular benefits due to its effects on weight and metabolic parameters【42†source】.

Relevant Academic Literature

  1. Endocrine Journal:

    • “Efficacy and Safety of Once-Weekly Semaglutide in Adults with Overweight or Obesity: A Meta-Analysis” Link【41†source】.

  2. Frontiers in Endocrinology:

    • “Efficacy and Safety of Semaglutide on Weight Loss in Obese or Overweight Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” Link【42†source】.

  3. JAMA:

    • “Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults with Overweight or Obesity: The STEP 4 Randomized Clinical Trial” Link【40†source】.

  4. New England Journal of Medicine:

    • “Once-Weekly Semaglutide in Adults with Overweight or Obesity” Link【41†source】.

These sources provide a comprehensive understanding of the safety and efficacy of semaglutide in the management of obesity, highlighting its significant weight loss benefits and acceptable safety profile.

中文提示

我是致力於實證醫學的醫生。
請提供關於 semaglutide 應用在肥胖症治療的安全性和有效性的證據概述。
列出相關的學術文獻。

ChatGPT 的回應

Semaglutide 應用於肥胖症治療的安全性和有效性概述

有效性

  1. 體重減輕：

    • Semaglutide 在肥胖患者中顯著減輕體重。研究一致報告，使用 semaglutide 的患者比使用安慰劑的患者體重減輕更多。
    • STEP 1 試驗顯示，每週一次注射 2.4 mg semaglutide 平均減輕體重約 15%，而安慰劑組僅減輕 2.4%【40†source】【41†source】。

  2. 體重維持：

    • 長期研究表明，semaglutide 有助於維持體重減輕效果。STEP 4 試驗顯示，持續使用 semaglutide 相較於安慰劑，在68週內顯著改善體重維持【41†source】。

  3. 合併症改善：

    • Semaglutide 不僅能減輕體重，還能改善多種與肥胖相關的合併症，如高血壓、血脂異常和糖尿病前期【42†source】。

安全性

  1. 常見副作用：

    • 最常報告的副作用為胃腸道症狀，包括噁心、嘔吐和腹瀉。這些副作用通常為輕度至中度，並隨時間減少【41†source】【42†source】。

  2. 嚴重不良事件：

    • 嚴重不良事件的發生率較低。部分研究指出膽囊相關事件和胰腺炎風險略有增加，但相對罕見【40†source】【41†source】。

  3. 心血管安全性：

    • Semaglutide 展示了良好的心血管安全性。它不會增加主要心血管不良事件（MACE）的風險，並且可能因其對體重和代謝參數的影響而提供一些心血管益處【42†source】。

相關學術文獻

  1. Endocrine Journal:

    • “Efficacy and Safety of Once-Weekly Semaglutide in Adults with Overweight or Obesity: A Meta-Analysis” 連結【41†source】。

  2. Frontiers in Endocrinology:

    • “Efficacy and Safety of Semaglutide on Weight Loss in Obese or Overweight Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” 連結【42†source】。

  3. JAMA:

    • “Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults with Overweight or Obesity: The STEP 4 Randomized Clinical Trial” 連結【40†source】。

  4. New England Journal of Medicine:

    • “Once-Weekly Semaglutide in Adults with Overweight or Obesity” 連結【41†source】。

這些文獻提供了 semaglutide 在肥胖管理中的安全性和有效性方面的全面理解，強調其顯著的體重減輕效果和可接受的安全性。

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